10
Jul
The other liver enzymes always seem to be behaving its just this one thats wonky. The last main reason why your dog has high ALP levels is because of a lack of Vitamin D.
These values go up from lots of different causes.
Dog very high alkp. Phenobarbital can benignly cause an elevated ALP but this medication can also cause liver damage. Because of this it is common for veterinarians to want to do more testing on the liver if a dog has an elevated ALP and is taking phenobarbital so she can differentiate between a benign and toxic liver change. As your pet moves from a puppy to a full-grown dog there is a natural increase in its ALP levels.
What causes high ALP in dogs. The normal ALP levels range from 20-200 units per liter. There are several factors that can lead to elevated alkaline phosphatase in dogs.
Cushings disease is one potential cause. That is when the adrenal glands produce more hormone which affects the. Not all alkaline phosphatase enzyme elevations are serious in dogs.
It is commonplace to see mild ALP elevations in older dogs due to normal aging changes to the liver. A normal aging change in older dogs is an ALP rise of no more than 2-3 times the upper end of the normal range. As you can imagine there are many potential causes of alkaline phosphatase elevation in cats and dogs given the different isoforms of the enzyme.
With that being said most causes of alkaline phosphatase are due to the liver bone andor corticosteroid isoforms. Some common causes are. My dog Sawyer who is 11 years old hound-mix male has elevated Alkaline Phosphataselevels ALPALKP.
The levels have been elevated for the past two years. All his other levels are in the normal range. He is currently on a raw diet and taking various supplements milk thistle digestive enzymes probiotics all prescribed by a holistic vet.
It should be noted that an elevated ALKP is a relatively common finding in older dogs and can be the result of idiopathic vacuolar hepatopathy. This is a benign process that can be confirmed with an abdominal ultrasound and liver biopsy though confirmation is often deemed unnecessary if liver function tests are normal and the dog seems to be in good health. The other liver enzymes always seem to be behaving its just this one thats wonky.
The normal range depends on the lab your veterinarian uses but most consider anything up to 130 or so as normal. Its not a shock at all to see a dog have an Alk-P of 200 even 400. It is true that ALKP can be elevated in a growing puppy because the bones are growing but it is pretty rare that I would attribute an increase in ALKP in an adult dog to bone disease.
The only thing that seems a slight bit abnormal to me is the elevated bile acid. My dogs alt is greater than 1000 alkp greater than 2000 ggt is 56- her Bun creatine are all fine. But she is not eating is having trouble walking with her hind legs.
I have more than 30 years of veterinary practice experience. I am sorry to hear about Lexi. The ALKP in the blood will increase when bile is not flowing properly out of the liver.
This may be because the liver is inflamed and thus preventing it. It will also increase with certain drugs hormonal diseases and bone growth in young dogs. Hi my dog 9 yr old is showing elevated ALP levels 232.
His triglyceride count is 49 as well after the blood test. What could be wrong. This is a very vague lab finding.
These values go up from lots of different causes. Your vet needs more testing to figure out if the liver is functioning properly. Some further tests include a bile.
There are many health conditions associated with an elevated ALP level in dogs. An elevated alkaline phosphatase level can be indicative of hepatitis inflammation of the liver pancreatitis inflammation of the pancreas diabetes bone or liver cancer viral or bacterial infections gall stones and Cushings disease. So if your dog is receiving steroids for any reason for any condition then that can cause a raised ALKP.
Also if your dog is Cushingoid if they have something known as hyperadrenocorticism when the adrenal glands are producing more stress hormones than they should do we can get a raised ALKP because that increased steroid causes this form to be. If your pet has a history of having an elevated ALKP level with or without signs of illness your veterinarian may recommend rechecking the level at some point to monitor whether it is changing. Additional testing may be advised if the level does not return to normal.
For a pet with high ALP depending on how high it is. I would also be suspicious and test for Cushings Disease. Typically liver disease will cause an increase in ALT AST and ALP.
The test of choice to determine if this is really liver is a test called the bile acid test. High ALT in dogs can be an indicator of liver cell damage so it should always be a sign to look deeper for serious liver damage. ALP Alkaline Phosphatase ALP is an enzyme that is found in highest concentration in the liver and the bone.
This is when your dog has weak bones which mainly happens due to either genetics or maintaining a poor diet for your dog. The last main reason why your dog has high ALP levels is because of a lack of Vitamin D. There are some minor reasons why your dog could be having high levels of ALP.
These are changes in their diet and lifestyle. Canine globulin levels normally fall between 2 and 38 grams per deciliter in the blood. As the globulins rise above this level due to overproduction the blood becomes thicker and less likely to flow well through the blood vessels.
This can result in poor circulation which leads to a variety of signs. Elevations of ALKP can also be induced by medications particularly corticosteroids and anticonvulsants. ALKP will also frequently be elevated in dogs with Cushings Disease hyperadrenocorticism an overactive adrenal gland.
Normal range is considered to be 10 to 150. I have seen numbers as high as 14000 GGT gamma glutamyl transpeptidase. The exact reasons for elevated alkaline phosphatase in pet dogs are not known as yet.
In majority of cases this abnormality is related to liver problems and bone diseases. It is estimated that a pet dog showing very high amounts of ALP has more than. The most common reason for a dog to have a high ALP is Cushings disease.
However she is a little young for this but it is still possible. Cushings is caused by the adrenal glands producing too much cortisol. Dogs with cushings tend to have an increase in thirst and appetite and often will have a pot-bellied appearance.
ALT level in dogs also increases due to extrahepatic diseases that secondarily affect the liver eg. In dogs the level of ALT moderately increases due to anticonvulsant therapy and biliary stasis. Other than these several other conditions cause an increase in the level of ALT in dogs.